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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
Chelerythrine |
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다른이름들 |
Heleritrine
Toddaline
1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium |
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함유 천연물 |
Chelidonium majus L.[]()
Zanthoxylum coreanum Nakai[왕초피나무(Wang-cho-pi-na-mu)](화초(花椒),초목(椒目)) |
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분 자 식 |
C21H18NO4 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
348.382 |
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녹 는 점 |
(Cl)207°C CHCl3/MeOH |
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생리학적효과 |
Potent cytotoxic agent functioning by DNA intercalation and uncoupling of oxidative phosphorylation. Inhibitor of rat liver aminotransferases. Antimicrobial and antiinflammatory agent recommended for use against oral infections. Temporary hypertensive agent in mice, rabbits and cats. Analgesic. Antineoplastic agent. Prolongs sleep. |
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UV_CHART |
(λmax, nm) (EtOH):(as Cl); 228(4.26), 272(4.54), 283 sh(4.47), 302 sh(4.37), 343(4.17) |
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HNMR_CHART |
(TFA-d,60 MHz) δ:(as Cl); 8.15(1H, s, H1), 7.57(1H, s, H4), 8.27(1H, d, 9.6, H5), 8.67(1H, d, 9.6, H6), 9.89(1H, s, H8), 8.72(1H, d, 9.6, H11), 8.22(1H, d, 9.6, H12), 5.12(3H, s, NMe), 4.26(3H, s, 10-OMe), 4.44(3H, s, 9-OMe), 6.31(2H, s, OCH2O) |
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참고문헌 |
· J. Slavik et al., Collect. Czech. Chem. Commun., 20, 21, 1955; 33, 1619, 1968(ms)
· BD. Krane et al., J. Nat. Prod., 47, 1, 1984
· V. Preininger et al., Planta Med., 50, 2, 149, 1984
· AS. Bailey et al., J. Chem. Soc., 4535, 1956
· L. Hruban et al., Coll. Czech. Chem. Comm., 35, 3420, 1970
· SV. Kessar et al., Indian J. Chem., 12, 323, 1974
· J. Smidrkal., Coll. Czech. Chem. Comm., 49, 1412, 1984
· M. Hanaoka et al., J. Chem. Soc. Perkin Trans. 1, 2253, 1986
· H. Ishii et al., Chem. Pharm. Bull., 40, 2002, 1992
· G. Martin et al., J. Org. Chem., 57, 5907, 1992 |
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