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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
Aconitine |
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함유 천연물 |
Aconitum carmichaeli Deb.[오두(烏頭)](부자(附子),흑순편(黑順片),백부편(白附片),염부자(鹽附子))
Aconitum ciliare DC.[선덩굴바꽃(Seon-deong-gul-ba-kkot)](초오(草烏))
Aconitum kusnezoffii Rchb.[이삭바꽃(I-sak-ba-kkot)]()
Aconitum proliferum Nakai[싹눈바꽃(Ssang-nun-ba-kkot)]()
Aconitum szechenyianum Gay.[-]()
Aconitum volubile Pall.[가는줄돌쩌귀(Ga-neun-jul-dol-jjeo-gwi)]() |
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분 자 식 |
C34H47NO11 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
645.754 |
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녹 는 점 |
203-205°C MeOH |
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생리학적효과 |
Toxic agent implicated in poisoning by Aconitum spp., esp. Aconitum chasmanthum in India, exp. arrhythmia effects. Gastric anaesthetic. Toxicity: Very toxic if swallowed or by skin absorption. Human systemic effects by ingestion. LD50 (mus, orl) 1 mg/kg, LD50 (mus, ivn) 0.175 mg/kg, exp. lethal doses by subcutaneous route reported. LD50 in mice (mg/kg): 0.166 i.v.; 0.328 i.p.; approx 1 orally (Dybing); also reported as LD50 in mice (mg/kg): 1.8 orally, 0.270 s.c.; 0.380 i.p.; 0.12 i.v. (Sato). |
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굴 절 율 |
[α]23 D = +19.0° (C 0.12,CHCl3) |
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HNMR_CHART |
δ:1.15(3H,t,NCH2CH3), 1.44(3H,s,OOCCH3), 3.29, 3.38, 3.42, 3.88(ea.3H,s,OMe), 5.04(1H,d,H14beta), 7.67-8.25(aromatic protons) |
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CNMR_CHART |
(CDCl3,25.0 MHz) δ: 83.4, 36.0, 70.4, 43.2, 46.6, 82.3, 44.8, 92.0, 44.2, 40.8, 49.8, 34.0, 74.0, 78.9, 78.9, 90.1, 61.0, 75.6, 48.8, 46.9, 13.3, 55.7, 57.9, 60.9, 58.9, 172.2, 21.3, 165.9, 129.6, 128.6, 129.8, 133.2, 129.8, 128.6 |
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참고문헌 |
· SW. Pelletier et al., J. Am. Chem. Soc., 98, 2626, 1976(pmr,cmr)
· S. Morio, Annalen, 476, 181, 1929
· M. Przybylska et al., Can. J. Chem., 37, 1116, 1843, 1959
· FW. Bachelor et al., Tetrahedron Lett., No. 10, 1, 1960
· KB. Birnbaum et al., Tetrahedron Lett., 867, 1971
· X. Chang et al., Yaoxue Xuebao, 16, 474, 1981; CA, 97, 3590f
· H. Hikino et al., J. Nat. Prod., 46, 178, 1983; 47, 190, 1984
· H. Wang et al., Heterocycles, 23, 803, 1985
· E. Arlandini et al., J. Nat. Prod., 50, 937, 1987
· HK. Desai et al., J. Nat. Prod., 52, 720, 1989
· WJ. Sun et al., Yaoxue Xuebao, 24, 71, 1989; CA, 111, 74778s
· H. Liu et al., J. Nat. Prod., 59, 135, 1996 |
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