코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Aconitine

함유 천연물 

Aconitum carmichaeli Deb.[오두(烏頭)](부자(附子),흑순편(黑順片),백부편(白附片),염부자(鹽附子))
Aconitum ciliare DC.[선덩굴바꽃(Seon-deong-gul-ba-kkot)](초오(草烏))
Aconitum kusnezoffii Rchb.[이삭바꽃(I-sak-ba-kkot)]()
Aconitum proliferum Nakai[싹눈바꽃(Ssang-nun-ba-kkot)]()
Aconitum szechenyianum Gay.[-]()
Aconitum volubile Pall.[가는줄돌쩌귀(Ga-neun-jul-dol-jjeo-gwi)]()

분 자 식 

C₃₄H₄₇NO₁₁

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

645.754

녹 는 점 

203-205°C MeOH

생리학적효과 

Toxic agent implicated in poisoning by Aconitum spp., esp. Aconitum chasmanthum in India, exp. arrhythmia effects. Gastric anaesthetic. Toxicity: Very toxic if swallowed or by skin absorption. Human systemic effects by ingestion. LD50 (mus, orl) 1 mg/kg, LD50 (mus, ivn) 0.175 mg/kg, exp. lethal doses by subcutaneous route reported. LD50 in mice (mg/kg): 0.166 i.v.; 0.328 i.p.; approx 1 orally (Dybing); also reported as LD50 in mice (mg/kg): 1.8 orally, 0.270 s.c.; 0.380 i.p.; 0.12 i.v. (Sato).

굴 절 율 

[α]23 D = +19.0° (C 0.12,CHCl3)

HNMR_CHART 

δ:1.15(3H,t,NCH2CH3), 1.44(3H,s,OOCCH3), 3.29, 3.38, 3.42, 3.88(ea.3H,s,OMe), 5.04(1H,d,H14beta), 7.67-8.25(aromatic protons)

CNMR_CHART 

(CDCl3,25.0 MHz) δ: 83.4, 36.0, 70.4, 43.2, 46.6, 82.3, 44.8, 92.0, 44.2, 40.8, 49.8, 34.0, 74.0, 78.9, 78.9, 90.1, 61.0, 75.6, 48.8, 46.9, 13.3, 55.7, 57.9, 60.9, 58.9, 172.2, 21.3, 165.9, 129.6, 128.6, 129.8, 133.2, 129.8, 128.6

참고문헌 

· SW. Pelletier et al., J. Am. Chem. Soc., 98, 2626, 1976(pmr,cmr) · S. Morio, Annalen, 476, 181, 1929 · M. Przybylska et al., Can. J. Chem., 37, 1116, 1843, 1959 · FW. Bachelor et al., Tetrahedron Lett., No. 10, 1, 1960 · KB. Birnbaum et al., Tetrahedron Lett., 867, 1971 · X. Chang et al., Yaoxue Xuebao, 16, 474, 1981; CA, 97, 3590f · H. Hikino et al., J. Nat. Prod., 46, 178, 1983; 47, 190, 1984 · H. Wang et al., Heterocycles, 23, 803, 1985 · E. Arlandini et al., J. Nat. Prod., 50, 937, 1987 · HK. Desai et al., J. Nat. Prod., 52, 720, 1989 · WJ. Sun et al., Yaoxue Xuebao, 24, 71, 1989; CA, 111, 74778s · H. Liu et al., J. Nat. Prod., 59, 135, 1996