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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
(+)-9-alpha-Hydroxymatrine |
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다른이름들 |
Matridin-15-one ((+)-form); 9alpha-Hydroxy
Lupanidine ((+)-form); 9alpha-Hydroxy |
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함유 천연물 |
Sophora flavescens Solander ex Aiton[고삼(Go-sam)](고삼(苦蔘),고삼실(苦蔘實),수괴(水槐),지괴(地槐))
Sophora macrocarpa[-]() |
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분 자 식 |
C15H24N2O2 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
264.371 |
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녹 는 점 |
158-159°Cpet. ether |
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굴 절 율 |
[α]20 D = +25.4° (C 1.0,MeOH) |
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HNMR_CHART |
(CDCl3,360 MHz) δ:1.31(1H,dd,12.3,4.7,H8), 1.83(1H,t,10.3,H10a), 2.25(1H,m,H14a), 2.43(1H,br dt,16.9,4.4,H14b), 2.83(1H,br d,10.3,H2), 2.98(1H,t,12.6,H17a), 3.03(1H,m,H10e), 3.64(1H,m,H11), 3.84(1H,m,H9), 4.39(1H,dd,12.6,4.5,H17e) |
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CNMR_CHART |
(CDCl3,20 MHz) δ: 18.95, 20.82, 27.32, 27.78, 32.83, 34.88, 35.71, 41.42, 44.17, 53.62, 57.04, 62.90, 62.99, 64.66, 169.33 |
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MASS_CHART |
EIM+= 264.184, m/z= 264(100), 263, 247, 246, 221, 219, 208, 205, 193, 166, 112, 98, 96 |
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참고문헌 |
· R. Negrete et al., Phytochemistry, 22, 2069, 1983(ir,pmr,cmr,ms)
· NC. Gonnella et al., Magn. Reson. Chem., 26, 185, 1988(pmr,cmr)
· S. Okuda et al., Chem. Pharm. Bull., 13, 482, 1965(ir)
· NS. Vul'dson et al., Khim. Geterotsikl. Soedin., 251, 1974(ms)
· F. Bohlmann et al., Chem. Ber., 91, 2176, 2189, 1958; 108, 1043, 1975
· HR. Schutte et al., Annalen, 685, 194, 1965
· L. Mandell et al., J. Am. Chem. Soc., 87, 5234, 1965
· A. Aslanov et al., CA, 67, 71108, 1967
· DD. Kamalitdinov et al., Khim. Prir. Soedin., 5, 409, 1969; Chem. Nat. Compd. (Engl. Transl.), 5, 340, 1969
· R. Kojima et al., Chem. Pharm. Bull., 18, 2555, 1970
· A. Ueno et al., Chem. Pharm. Bull., (footnote), 23, 2560, 1975
· K. Morinaga et al., Chem. Pharm. Bull., 26, 2483, 1978
· BT. Ibragimov et al., Khim. Prir. Soedin., 15, 416, 1979; Chem. Nat. Compd. (Engl. Transl.), 15, 368, 1979
· FJ. Leeper et al., Can. J. Chem., 59, 106, 1981
· RE. Negrete et al., Bol. Soc. Chil. Quim., 27, 263, 1982
· BT. Ibragimov et al., Khim. Prir. Soedin., 18, 71, 1982; Chem. Nat. Compd. (Engl. Transl.), 18, 66, 1982
· BA. Abdusalamov, Khim. Prir. Soedin., 20, 3, 1984; Chem. Nat. Compd. (Engl. Transl.), 20, 1, 1984
· T. Sakamoto et al., Chem. Pharm. Bull., 34, 2018, 1986 |
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