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 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

(+)-5-alpha,9-alpha-Dihydroxymatrine

다른이름들 

5,9-Dihydroxymatridin-15-one ((+)-form) Sophoranol ((+)-form); 9alpha-Hydroxy Sofranol; 9alpha-Hydroxy 5-Hydroxymatrine; 9alpha-Hydroxy 5-alpha-Hydroxymatrine ((+)-form); 9alpha-Hydroxy

함유 천연물 

Sophora flavescens Solander ex Aiton[고삼(Go-sam)](고삼(苦蔘),고삼실(苦蔘實),수괴(水槐),지괴(地槐))

분 자 식 

C₁₅H₂₄N₂O₃

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

280.37

녹 는 점 

192-193°C Me2CO

굴 절 율 

[α]20 D = +40.6° (C 0.17,EtOH)

HNMR_CHART 

(CDCl3,100 MHz) δ:4.31(1H, dd, 13.5, 1, H17 eq.), 3.79(1H, m, H11), 3.67(1H, m, H9), 3.17(1H, d, 13.5, H17 ax.), 3.05(1H, br dd, 10, 4, H10 eq.), 2.78(1H, br d, 10, H2 eq.)

CNMR_CHART 

(CDCl3,25 MHz) δ: 56.3, 22.5, 36.9, 68.0, 37.2, 38.4, 35.0, 62.7, 34.0, 53.8, 26.8, 18.6, 32.6, 171.2, 46.5

MASS_CHART 

M+= 280, m/z= 263, 221, 112, 55(100)

참고문헌 

· S. Ohmiya et al., Phytochemistry, 18, 645, 1979(ir,pmr,cmr,ms) · F. Bohlmann et al., Chem. Ber., 91, 2189, 1958 · S. Okuda et al., Chem. Pharm. Bull., 13, 482, 1965 · S. Ohmiya et al., Phytochemistry, 18, 648, 1978 · I. Murakoshi et al., Phytochemistry, 21, 2379, 1982