코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Sophoranol ((+)-form)

다른이름들 

Sofranol 5-Hydroxymatrine 5-alpha-Hydroxymatrine ((+)-form)

함유 천연물 

Sophora flavescens Solander ex Aiton[고삼(Go-sam)](고삼(苦蔘),고삼실(苦蔘實),수괴(水槐),지괴(地槐))
Sophora macrocarpa[-]()

분 자 식 

C₁₅H₂₄N₂O₂

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

264.371

녹 는 점 

171°C

생리학적효과 

CNS depressant effect, sedative, hypnotic, anticonvulsion properties & no analgesic effect.

굴 절 율 

[α]20 D = +66°( H2O)

HNMR_CHART 

(CDCl3,100 MHz) δ:4.34(dd, H17 eq.), 3.21(d, H17 ax.), 3.77(m, H11), 2.75(br d, H2 eq.), 2.86(br d, H10 eq.)

CNMR_CHART 

(CDCl3) δ: 56.6(C2), 20.4(C3), 36.5(C4), 67.7(C5), 68.5(C6), 36.8(C7), 26.0(C8), 22.5(C9), 56.9(C10), 53.1(C11), 26.7(C12), 18.8(C13), 32.7(C14), 46.5(C17)

MASS_CHART 

EIM+= 264.184, m/z= 263, 247, 246, 222, 221, 208, 166, 112, 112, 98, 96

참고문헌 

· F. Bohlmann et al., Chem. Ber., 108, 1043, 1975(cmr) · A. Ueno et al., Chem. Pharm. Bull., 26, 1832, 1978 · S. Okuda et al., Chem. Pharm. Bull., 13, 482, 1965 · S. Ohmiya et al., Phytochemistry, 18, 645, 1979(pmr) · F. Bohlmann et al., Chem. Ber., 91, 2189, 1958 · AM. Abdel-Baky et al., Fitoterapia, 58, 5, 295, 1987 · S. Ohmiya et al., Chem. Pharm. Bull., 28, 546, 1980